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Millions of patients die annually from diseases that affect organs with limited regenerative capacity such as the heart. In contrast, zebrafish regenerate most organs naturally after injury. The goal of our research is to identify barriers to heart regeneration using the zebrafish as a model organism. Our lab is particularly interested in understanding how polyploidization (the increase in DNA content associated with the maturation of certain cell types) reduces the regenerative competence of cardiomyocytes. Our ultimate goal is to make fundamental discoveries that could be later used to design strategies to regenerate the human heart after myocardial infarction.

Dr. Gonzalez-Rosa received his PhD in Molecular Biology from the Universidad Autonoma (Madrid) and the Spanish National Center for Cardiovascular Research in 2013. During his thesis work under the supervision of Dr. Nadia Mercader, he pioneered the development of a new cryoinjury model to study zebrafish heart regeneration. In October 2013, Dr. Gonzalez-Rosa joined the laboratory of Caroline and Geoffrey Burns at Massachusetts General Hospital and Harvard Medical School. As a postdoctoral researcher, his research was supported by a Long-Term Postdoctoral Fellowship from EMBO and the Funds for Medical Discovery Award from ECOR-MGH. In June 2019, Dr. Gonzalez-Rosa joined the CVRC faculty after receiving the Career Development Award from the American Heart Association.

1)听听听听[热点爆料入口] Keeley S*, Fern谩ndez-Lajar铆n M*, Bergemann D, John N**, Parrott L**, Andrea BE,聽Gonz谩lez-Rosa JM听(2024). .听bioRxiv;听doi: 10.1101/2024.09.27.615502.听(*Keeley and Fern谩ndez-Lajar铆n, co-first authors).

2)听听听听[热点爆料入口]聽Sande-Melon M, Bergemann D, Fern谩ndez-Lajar铆n M,聽Gonz谩lez-Rosa JM*, Cox AG*. .听Development. 2024 Jul 8:dev.203124.听PMID: 38975841. (* Gonz谩lez-Rosa and Cox, co-corresponding).

3)听听听听[热点爆料入口]聽Akam EA, Bergemann D, Ridley SJ, To S, Andrea B, Moon B, Ma H, Zhou Y, Aguirre A, Caravan P,聽Gonzalez-Rosa JM, Sosnovik DE (2024). Dynamics of Collagen Oxidation and Cross Linking in Regenerating and Irreversibly Infarcted Myocardium.听Nat Commun. 2024 Jun 10;15(1):4648.听PMID: 38858347.

4)听听听听Bhavsar H, Robinson Z, Benson M, Getachew F,聽Gonz谩lez-Rosa JM, Lafontant PJ.听(2024) (Danio rerio) Liver.听Zebrafish聽Apr;21(2):177-180.听PMID: 38621207

5)听听听听Da Silveira Cavalcante L, Lopera Higuita M,聽Gonz谩lez-Rosa JM, Marques B, To S, Pendexter CA, Cronin SEJ, Gopinathan K, de Vries RJ, Ellett F, Uygun K, Langenau DM, Toner M, Tessier SN.听(2023). .听FASEB J. Oct;37(10):e23187.听PMID: 37718489.

6)听听听听Li H, Trager LE, Liu X, Hastings MH, Xiao C, Guerra J, To S, Li G, Yeri A, Rodosthenous R, Silverman MG, Das S, Ambardekar AV, Bristow M,聽Gonzalez-Rosa JM, Rosenzweig A (2022). .听Circulation, Apr 19;145(16):1218-1233.听PMID: 35114812.

7)听听听听Gonz谩lez-Rosa JM. (2022) .听Circ Res聽10;130(12):1803-1826.听PMID: 35679360.